Apple Seeds Fourth Beta of macOS Sierra 10.12.5 to Developers [Update: Public Beta Too]
Apple today seeded the fourth beta of an upcoming macOS Sierra 10.12.5 update to developers, one week after seeding the third beta and one month after releasing macOS Sierra 10.12.4, which introduced Night Shift for the Mac.
The fourth beta of macOS Sierra 10.12.5 can be downloaded through the Apple Developer Center or through the Software Update mechanism in the Mac App Store.

According to the release notes accompanying the beta, the update "improves the stability, compatibility, and security of your Mac."
Apple's release notes don't often provide a lot of insight into what's included in new beta software, so we don't know what features or bug fixes might be included in the 10.12.5 update.
No notable changes or major bug fixes were discovered in the first three betas, but should anything pop up in the fourth macOS Sierra 10.12.5 beta, we'll update this post.
Update: Apple has also provided the fourth beta of macOS Sierra 10.12.5 to public beta testers.
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Top Rated Comments
Apt username, too.
* It's a Beta. There are no 'releases' of macOS 10.12.5 yet.
* HandBrake works fine for me and apparently other people in the forum
* It's a Developers Preview and something tells me that you are not much of a developer if you feel you needed to throw a fit that an app is not working on your primary Mac (of which you shouldn't be installing this preview on)
EDIT: BTW you probably shouldn't try the public beta either
Anyhow, it's obviously an isolated issue, as my Handbrake works just fine, and you're the ONLY one on here that's say it doesn't work. Every other post says it works fine.
If you can't live without ANY single app working on your computer, DO NOT INSTALL BETAS.
Sierra was one hell of a stable OS when released, the next one might be the same or better.