The bump up to 50 means bigger team chats and larger conference calls with speakers can take place, while full classes of students can participate in group calls.
The change also means Microsoft's Skype now beats Apple's FaceTime for the number of users that take part in a group call. FaceTime supports a maximum of 32 people.
In addition, Microsoft has made some changes to how larger Skype group calls start. Users now receive a notification to replace the default ringing sound, which is meant to allow every member of a group to receive a quick ping to join the call in a more unobtrusive way.
The audio and video buttons remain available to use in larger groups, so users can still mute their microphones or turn on/off their webcam.
Large group calling is available on the latest version of Skype for desktop and mobile.